Pheno2Geno-High-throughput generation of genetic markers and maps from molecular phenotypes for crosses between inbred strains

Abstract

Pheno2geno is a R package for the detection of biomarkers and the construction of genetic maps from molecular phenotypes in segregating inbred populations. Molecular phenotypes such as RNA transcript abundance with a clearly separated bi-modal or multi-modal expression distribution are detected as candidate markers. Quality control is applied to the candidate markers, and suitable ones are the transformed into discrete (genetic) biomarkers. Pheno2geno uses these detected biomarkers to saturate an existing genetic map or even construct a genetic map de novo.

Publication
BMC Bioinformatics 2015 16:51
Date